Shake the oral suspension liquid well just before you measure a dose. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one. Avoid taking aspirin while you are taking Treximet. When treating acute painful conditions, the delayed release form is not recommended due to delay in absorption. Warfarin is a prescription drug, and the prescription labeling includes a warning that acetaminophen can interfere with the thinning action of warfarin. Serotonin release by platelets plays an important role in hemostasis. Case-control and cohort epidemiological studies showed that concomitant use of drugs that interfere with serotonin reuptake and an NSAID may potentiate the risk of bleeding more than an NSAID alone. decadron
This warning must read: "This product contains a nonsteroidal anti-inflammatory drug NSAID which may cause severe stomach bleeding. The chance is higher if you are age 60 or older, have had stomach ulcers or bleeding problems, take a blood thinning or steroid drug, take other drugs containing prescription or nonprescription NSAIDs, have three or more alcoholic drinks every day using this product, take more or for a longer time than directed. Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. In these patients, administration of an NSAID may cause a dose-dependent reduction in prostaglandin formation and, secondarily, in renal blood flow, which may precipitate overt renal decompensation. Patients at greatest risk of this reaction are those with impaired renal function, dehydration, hypovolemia, heart failure, liver dysfunction, those taking diuretics and ACE inhibitors or ARBs, and the elderly. Discontinuation of NSAID therapy is usually followed by recovery to the pretreatment state.
But people should be careful drawing conclusions from this latest finding, Antman added. The study was not a randomized trial, he noted, and the available data left some important questions unanswered. This effect helps to decrease swelling, pain, or fever. Concomitant administration of cholestyramine with NAPROSYN Tablets, EC-NAPROSYN, or ANAPROX DS is not recommended.
Nonsteroidal Anti-Inflammatory Agents. Management: Seek alternatives to the combined use of diclofenac with other nonsteroidal anti-inflammatory agents NSAIDs. Agents with Antiplatelet Properties. Specifically, the risk of bleeding may be increased by concurrent use of these agents. NSAIDs cause an increased risk of serious gastrointestinal GI adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Symptomatic improvement of arthritis is usually observed within 1 week; however, treatment for 2 weeks may be required to achieve therapeutic benefit.
Avoid use in patients with a recent MI unless benefits outweigh risk of cardiovascular thrombotic events. Use the lowest effective dose for the shortest duration of time, consistent with individual patient goals, to reduce risk of cardiovascular events; alternate therapies should be considered for patients at high risk. But taking aspirin isn't right for everyone, because it can cause serious bleeding. Talk to your doctor before you start taking aspirin every day. Teva Pharmaceuticals USA, Inc. In patients taking NSAIDs, the following adverse experiences have also been reported in approximately 1% to 10% of patients. That category of NSAIDs was associated with a 17 percent increase in postmenopausal women's risk of or stroke, compared to a 13 percent increase associated with NSAIDs that specifically target and inhibit cox-2. Elimination of naproxen is decreased in patients with severe renal impairment. Drospirenone: Nonsteroidal Anti-Inflammatory Agents may enhance the hyperkalemic effect of Drospirenone. NSAIDs are one of two major types of OTC pain relievers. The other is acetaminophen Tylenol. You should not use naproxen if you are allergic to it, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID. NSAID-related GI symptoms. These studies indicated that naproxen delayed-release tablets and naproxen tablets showed no significant differences in efficacy or safety and had similar prevalence of minor GI complaints. Individual patients, however, may find one formulation preferable to the other. Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. Tipranavir: May enhance the antiplatelet effect of Agents with Antiplatelet Properties. Sumatriptan and naproxen can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are taking this medication. Do not crush, chew, or break a naproxen tablet. Swallow it whole. GI bleed compared to patients without these risk factors.
The concomitant use of naproxen with other NSAIDs or salicylates is not recommended. ACE inhibitors or ARBs, and the elderly. Naproxen enteric-coated tablets comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get naproxen enteric-coated tablets refilled. Prior research has found that specifically inhibiting cox-2 can increase heart attack and stroke risk, so much so that two NSAIDs that targeted cox-2 -- Vioxx and Bextra -- were pulled from the market for safety reasons in the mid-2000s. The study is published in the July issue of Circulation: Cardiovascular Quality and Outcomes, an American Heart Association journal. GI bleeding are at greater risk of serious GI events. These events may occur at any time during therapy and without warning. Avoid use in patients with active GI bleeding. Older adults should usually take lower doses of naproxen for short periods of time because higher doses used regularly may not be more effective and are more likely to cause serious side effects. Call your doctor for medical advice about side effects. Prescription naproxen is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis arthritis caused by a breakdown of the lining of the joints rheumatoid arthritis arthritis caused by swelling of the lining of the joints juvenile arthritis a form of joint disease in children and ankylosing spondylitis arthritis that mainly affects the spine. Prescription naproxen tablets, extended-release tablets, and suspension are also used to relieve shoulder pain caused by bursitis inflammation of a fluid-filled sac in the shoulder joint tendinitis inflammation of the tissue that connects muscle to bone gouty arthritis attacks of joint pain caused by a build-up of certain substances in the joints and pain from other causes, including menstrual pain pain that happens before or during a menstrual period. Nonprescription naproxen is used to reduce fever and to relieve mild pain from headaches, muscle aches, arthritis, menstrual periods, the common cold, toothaches, and backaches. Naproxen is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation. If you are taking this drug on a regular schedule not just "as needed" and you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip themissed dose and resume your usual dosing schedule. Consult WARNINGS section for additional precautions. No evidence of tumorigenicity was found. vasotec
Patients simultaneously receiving naproxen delayed-release tablets and probenecid should be observed for adjustment of dose if required. Aliskiren: Nonsteroidal Anti-Inflammatory Agents may diminish the antihypertensive effect of Aliskiren. Nonsteroidal Anti-Inflammatory Agents may enhance the nephrotoxic effect of Aliskiren. Management: Monitor renal function periodically in patients receiving aliskiren and any nonsteroidal anti-inflammatory agent. Patients at elevated risk of renal dysfunction include those who are elderly, are volume depleted, or have pre-existing renal dysfunction. Two large, controlled, clinical trials of a COX-2 selective NSAID for the treatment of pain in the first 10 to 14 days following CABG surgery found an increased incidence of myocardial infarction and stroke. This may not be a complete list of all interactions that may occur. Ask your health care provider if naproxen enteric-coated tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. Aluminum Lake, magnesium stearate, methacrylic acid copolymer-dispersion, povidone, propylene glycol, shellac, talc, titanium dioxide, and triethyl citrate. Prior to initiating treatment, the potential benefits and risks of this drug should be weighed against other treatment options. In some countries, this medicine may only be approved for veterinary use. This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use and wear protective clothing when outdoors. When these drugs are administered concomitantly, patients should be adequately hydrated. Assess renal function at the beginning of the concomitant treatment and periodically thereafter. Concomitant use of naproxen delayed-release tablets and pemetrexed may increase the risk of pemetrexed-associated myelosuppression, renal, and GI toxicity see the pemetrexed prescribing information. Holman says within a year over-the counter- containing acetaminophen or NSAIDs must carry bolder warnings about risks such as stomach bleeding and liver damage. effexor how to purchase canada effexor
MRDH based on body surface area. Naproxen sodium is not recommended for children under 2. Ibuprofen is considered safe for children 6 months and older in the right dose. To minimize the potential risk for an adverse CV event in NSAID-treated patients, use the lowest effective dose for the shortest duration possible. Physicians and patients should remain alert for the development of such events, throughout the entire treatment course, even in the absence of previous CV symptoms. Patients should be informed about the symptoms of serious CV events and the steps to take if they occur. Salicylates. Increased risk of bleeding may result. Do not use a nonprescription NSAID for longer than 10 days without talking to your doctor. Oral Suspension: Avoid excessive heat above 40C 104F. Probenecid given concurrently increases naproxen anion plasma levels and extends its plasma half-life significantly. It may harm them. Use is not recommended; avoid use in patients with advanced renal disease. If you will be undergoing a coronary artery bypass graft CABG; a type of heart surgery you should not take naproxen right before or right after the surgery. White to off-white, capsule-shaped, enteric-coated, unscored tablets imprinted on one side in blue ink with 93-6. They are available in bottles of 100 NDC 0093-1006-01 and 500 NDC 0093-1006-05 tablets. If your symptoms do not improve or if they become worse, check with your doctor. misoprostol stock price news
Use naproxen enteric-coated tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions. Alert patients that NSAIDs may be present in “over the counter” medications for treatment of colds, fever, or insomnia. Ask a doctor or pharmacist before using any cold, allergy, or pain medicine. Many medicines available over the counter contain aspirin or other medicines similar to naproxen. Taking certain products together can cause you to get too much of this type of medication. Check the label to see if a medicine contains aspirin, ibuprofen, ketoprofen, or naproxen. Concerns have been raised about the long-term safety of more traditional anti-inflammatory pain relievers. In an effort to better understand the risks, Garcia Rodriguez and colleague Antonio Gonzalez-Perez of the Spanish Center for Pharmacoepidemiological Research assessed the short- and long-term use of NSAIDs as a class and also looked specifically at three of the most commonly used NSAIDs. Anaphylactoid reactions: Even in patients without prior exposure anaphylactoid reactions may occur; patients with "aspirin triad" bronchial asthma, aspirin intolerance, rhinitis may be at increased risk. Contraindicated in patients who experience bronchospasm, asthma, rhinitis, or urticaria with NSAID or aspirin therapy. Naproxen Delayed-Release Tablets USP: 500 mg: white to off-white, capsule-shaped, enteric-coated, unscored tablets imprinted on one side in blue ink with 93-6. If you take antacids or cholestyramine, ask your doctor or pharmacist how to take them with naproxen enteric-coated tablets. Adverse reactions reported in controlled clinical trials in 960 patients treated for rheumatoid arthritis or osteoarthritis are listed below. In general, reactions in patients treated chronically were reported 2 to 10 times more frequently than they were in short-term studies in the 962 patients treated for mild to moderate pain or for dysmenorrhea. The most frequent complaints reported related to the gastrointestinal tract. Avoid taking NSAIDs after a recent heart attack, unless your healthcare provider tells you to. You may have an increased risk of another heart attack if you take NSAIDs after a recent heart attack. Use is not recommended in patients with moderate renal impairment. But it's crucial if you use any of the pain relievers that can make your get worse. Adults: The initial dose is 400 mg. Follow-up doses are 200 mg to 400 mg every 4 hours as needed, up to a maximum of 4 doses in a 24-hour period. Based on animal data, prostaglandins have been shown to have an important role in endometrial vascular permeability, blastocyst implantation, and decidualization. In animal studies, administration of prostaglandin synthesis inhibitors such as naproxen, resulted in increased pre- and post-implantation loss. Take orally with a full glass of water; take with food or milk if stomach upset occurs. esro.info nimotop
What are the possible side effects of NSAIDs? Agents with Antiplatelet Properties. Bleeding may occur. Probenecid: May increase the serum concentration of Nonsteroidal Anti-Inflammatory Agents. If you are taking naproxen to relieve the symptoms of arthritis, your symptoms may begin to improve within 1 week. It may take 2 weeks or longer for you to feel the full benefit of the medication. CV thrombotic events is similar for all NSAIDs. Take this medication by as directed by your doctor, usually twice daily with or without food. Swallow this medication whole. not break, crush, or chew the tablets. Doing so can release the drug too quickly, increasing the risk of side effects. Anticoagulants: Agents with Antiplatelet Properties may enhance the anticoagulant effect of Anticoagulants. Bile Acid Sequestrants: May decrease the absorption of Nonsteroidal Anti-Inflammatory Agents.
Nonprescription naproxen comes as tablet and a gelatin coated tablet to take by mouth. It is usually taken with a full glass of water every 8 to 12 hours as needed. Nonprescription naproxen may be taken with food or milk to prevent nausea. When it comes to choosing and using NSAIDs, Antman offers this advice: “Generally, your best option is to take the least risky drug, at the lowest dose you need to control your pain, for the shortest amount of time possible. Refer to adult dosing. The rules are intended "to reduce the incidence and seriousness of liver damage caused by acetaminophen and stomach bleeding caused by NSAIDs. Tolperisone. Specifically, the risk of hypersensitivity reactions may be increased. Tolperisone may enhance the therapeutic effect of Nonsteroidal Anti-Inflammatory Agents. Naproxen enteric-coated tablets may interfere with certain lab tests. Be sure your doctor and lab personnel know that you take naproxen enteric-coated tablets. For products containing acetaminophen, labels must bear the medication's name "prominently" and in highlighted text on the front, says Holman, deputy director of the FDA's Division of Nonprescription Regulation Development. Clinical trials of several COX-2 selective and nonselective NSAIDs of up to three years duration have shown an increased risk of serious cardiovascular CV thrombotic events, including myocardial infarction MI and stroke, which can be fatal. Based on available data, it is unclear that the risk for CV thrombotic events is similar for all NSAIDs. The relative increase in serious CV thrombotic events over baseline conferred by NSAID use appears to be similar in those with and without known CV disease or risk factors for CV disease. However, patients with known CV disease or risk factors had a higher absolute incidence of excess serious CV thrombotic events, due to their increased baseline rate. Some observational studies found that this increased risk of serious CV thrombotic events began as early as the first weeks of treatment. The increase in CV thrombotic risk has been observed most consistently at higher doses. HydrALAZINE: Nonsteroidal Anti-Inflammatory Agents may diminish the antihypertensive effect of HydrALAZINE. generic acticin name
Use: For the acute treatment of migraine with or without aura. Naproxen has been studied in patients with rheumatoid arthritis, osteoarthritis, polyarticular juvenile idiopathic arthritis, ankylosing spondylitis, tendonitis and bursitis, and acute gout. Improvement in patients treated for rheumatoid arthritis was demonstrated by a reduction in joint swelling, a reduction in duration of morning stiffness, a reduction in disease activity as assessed by both the investigator and patient, and by increased mobility as demonstrated by a reduction in walking time. Generally, response to naproxen has not been found to be dependent on age, sex, severity or duration of rheumatoid arthritis. During concomitant use of NAPROSYN Tablets, EC-NAPROSYN, or ANAPROX DS and cyclosporine, monitor patients for signs of worsening renal function. Naproxen can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine. How we experience pain and the amount of pain relief we get from NSAIDs varies from person to person. What should I discuss with my healthcare provider before taking Anaprox naproxen? To help prevent these side effects, take NSAIDs with food and a glass of water. Naproxen tested positive in the in vivo sister chromatid exchange assay for but was not mutagenic in the in vitro bacterial reverse mutation assay Ames test. This effect should be kept in mind when bleeding times are determined. Ask your doctor before using an antacid, and use only the type your doctor recommends. Some antacids can make it harder for your body to absorb naproxen. Patients should seek medical advice for signs and symptoms of gastrointestinal events, adverse skin reactions, allergic reactions, hepatotoxicity, or unexplained weight gain or edema. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: angiotensin-converting enzyme ACE inhibitors such as benazepril Lotensin, in Lotrel captopril, enalapril Vasotec, in Vaseretic fosinopril, lisinopril in Zestoretic moexipril Univasc perindopril Aceon, in Prestalia quinapril Accupril, in Quinaretic ramipril Altace and trandolapril Mavik, in Tarka; angiotensin receptor blockers ARBs such as azilsartan Edarbi, in Edarbyclor candesartan Atacand, in Atacand HCT eprosartan Teveten irbesartan Avapro, in Avalide losartan Cozaar, in Hyzaar olmesartan Benicar, in Azor, in Benicar HCT, in Tribenzor telmisartan Micardis, in Micardis HCT, in Twynsta and valsartan in Exforge HCT; beta blockers such as atenolol Tenormin, in Tenoretic labetalol Trandate metoprolol Lopressor, Toprol XL, in Dutoprol nadolol Corgard, in Corzide and propranolol Hemangeol, Inderal, InnoPran; cholestyramine Prevalite; diuretics 'water pills'; lithium Lithobid medications for diabetes; methotrexate Otrexup, Rasuvo, Trexall; probenecid Probalan; Col-Probenecid; and sulfa medications such as sulfamethoxazole in Bactrim, in Septra. If you are taking the delayed-release tablets, also tell your doctor if you are taking antacids or sucralfate Carafate. Your doctor may need to change the doses of your medication or monitor you more carefully for side effects. Recommended dosages and duration should not be exceeded, due to an increased risk of GI bleeding, MI, and stroke. Carefully consider the potential benefits and risks of naproxen delayed-release tablets and other treatment options before deciding to use naproxen delayed-release tablets. If you would like more information about NSAIDs, talk with your healthcare provider. You can ask your pharmacist or healthcare provider for information about NSAIDs that is written for health professionals. In 51Cr blood loss and gastroscopy studies with normal volunteers, daily administration of 1000 mg of naproxen as 1000 mg of naproxen or 1100 mg of naproxen sodium has been demonstrated to cause statistically significantly less gastric bleeding and erosion than 3250 mg of aspirin. can i amantadine online
If you use naproxen long-term, you may need frequent medical tests. Ask a doctor or pharmacist before using any cold, allergy, or pain medication. Many medicines available over the counter contain aspirin or other medicines similar to naproxen. Taking certain products together can cause you to get too much of this type of medication. Check the label to see if a medicine contains aspirin, ibuprofen, ketoprofen, or naproxen. Salicylates. An increased risk of bleeding may be associated with use of this combination. NSAID Nonselective may diminish the cardioprotective effect of Salicylates. Salicylates may decrease the serum concentration of NSAID Nonselective. Exceptions: Choline Magnesium Trisalicylate. Joel Schiffenbauer, MD, deputy director of the Division of Nonprescription Clinical Evaluation at the FDA Center for Drug Evaluation and Research. Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients. So before you reach for one of the many bottles on the drugstore shelf, read on to learn about one type of OTC pain relievers -- non-steroidal anti-inflammatory drugs NSAIDs -- and the benefits and risks of taking them. How Do NSAIDs Relieve Pain? Prescription naproxen comes as a regular tablet, a delayed-release a tablet that releases the medication in the intestine to prevent damage to the stomach tablet, an extended-release long-acting tablet, and a suspension liquid to take by mouth. The extended-release tablets are usually taken once a day. The tablets, delayed-release tablets, and suspension are usually taken twice a day for arthritis. The tablets and suspension are usually taken every 8 hours for gout, and every 6 to 8 hours as needed for pain. If you are taking naproxen on a regular basis, you should take it at the same times every day. Other side effects of NSAIDs include: stomach pain, constipation, diarrhea, gas, heartburn, nausea, vomiting, and dizziness. NPR LE 500 on one side and scored on the other. Nonsteroidal anti-inflammatory drugs NSAIDs cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction MI and stroke, which can be fatal. This risk may occur early in treatment and may increase with duration of use. Stronger doses of some of these drugs, as well as other NSAIDs, are also available by prescription. Avoid administration of more than one NSAID at a time. benicar purchase shopping usa
Porfimer: Photosensitizing Agents may enhance the photosensitizing effect of Porfimer. PREGNANCY and BREAST-FEEDING: Naproxen enteric-coated tablets may cause harm to the fetus. Do not use it during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using naproxen enteric-coated tablets while you are pregnant. Naproxen enteric-coated tablets should not be used during labor. Naproxen enteric-coated tablets are found in breast milk. If you are or will be breast-feeding while you use naproxen enteric-coated tablets, check with your doctor. Discuss any possible risks to your baby. Forced diuresis, alkalinization of urine, hemodialysis, or hemoperfusion may not be useful due to high protein binding. Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure as required. NSAIDs should interrupt dosing for at least five days before, the day of, and two days following pemetrexed administration. Since 2005, labeling laws have required a heart warning on these anti-inflammatory drugs. That warning stemmed from Merck's withdrawal of the NSAID Vioxx from the market in 2004 because of a notable increased risk of among Vioxx users. Elevations of ALT or AST less than three times ULN may occur in up to 15% of patients treated with NSAIDs including naproxen. Teva Pharmaceutical IND. LTD. Take NSAIDs with food and water. CycloSPORINE Systemic: Nonsteroidal Anti-Inflammatory Agents may enhance the nephrotoxic effect of CycloSPORINE Systemic. Nonsteroidal Anti-Inflammatory Agents may increase the serum concentration of CycloSPORINE Systemic. CycloSPORINE Systemic may increase the serum concentration of Nonsteroidal Anti-Inflammatory Agents. Management: Consider alternatives to nonsteroidal anti-inflammatory agents NSAIDs. Monitor for evidence of nephrotoxicity, as well as increased serum cyclosporine concentrations and systemic effects eg, hypertension during concomitant therapy with NSAIDs. Selective Serotonin Reuptake Inhibitors: May enhance the antiplatelet effect of NSAID Nonselective. NSAID Nonselective may diminish the therapeutic effect of Selective Serotonin Reuptake Inhibitors. Do not crush or chew this medication. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing. Concomitant use of NAPROSYN Tablets, EC-NAPROSYN, or ANAPROX DS and pemetrexed may increase the risk of pemetrexed-associated myelosuppression, renal, and GI toxicity see the pemetrexed prescribing information. quibron
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PRALAtrexate: Nonsteroidal Anti-Inflammatory Agents may increase the serum concentration of PRALAtrexate. More specifically, NSAIDS may decrease the renal excretion of pralatrexate. Always take these medicines exactly as prescribed or according to the label. Use: For the acute treatment of migraine with or without aura in patients 12 years of age or older. Treximet is not approved for use by anyone younger than 12 years old. The oral suspension is recommended due to flexible dose titration based on patient's weight. order generic esomeprazole store australia
This difference should be taken into consideration when changing strengths or formulations. Tablet, delayed or extended release: Swallow tablet whole; do not break, crush, or chew. Renal effects: NSAID use may compromise existing renal function; dose-dependent decreases in prostaglandin synthesis may result from NSAID use, reducing renal blood flow which may cause renal decompensation usually reversible. Patients with impaired renal function, dehydration, hypovolemia, heart failure, hepatic impairment, those taking diuretics, and ACE inhibitors, and the elderly are at greater risk of renal toxicity. Rehydrate patient before starting therapy; monitor renal function closely. Long-term NSAID use may result in renal papillary necrosis and other renal injury.
Ibritumomab. Both agents may contribute to impaired platelet function and an increased risk of bleeding. When treating patients, especially at higher doses, sufficient increased clinical benefit should be observed to offset the potential for increased risk of adverse events. Hyperkalemia: NSAID use may increase the risk of hyperkalemia, particularly in the elderly, diabetics, renal disease, and with concomitant use of other agents capable of inducing hyperkalemia eg, ACE-inhibitors. Monitor potassium closely. Avoid use in patients at higher risk unless benefits are expected to outweigh the increased risk of bleeding. For such patients, as well as those with active GI bleeding, consider alternate therapies other than NSAIDs.
If you change brands, strengths, or forms of naproxen, your dosage needs may change. Ask your pharmacist if you have any questions about the kind of naproxen you are using. In patients who are elderly, volume-depleted including those on diuretic therapy or have renal impairment, co-administration of an NSAID with ACE inhibitors or ARBs may result in deterioration of renal function, including possible acute renal failure. These effects are usually reversible. EC 500 on one side. Packaged in light-resistant bottles of 100.